Histamine works with your body through four main helpers called receptors, each with a different job:
H1 Receptors:
Where? Mostly in muscles, blood vessels, and the brain.
What do they do? They cause allergic reactions like itching, hives, and stuffy noses. They also help control when you're awake or sleepy and how hungry you feel.
What happens? When histamine connects to H1 receptors, it makes blood vessels wider, causes swelling, and tightens muscles, leading to symptoms like redness and itching.
H2 Receptors:
Where? Mostly in your stomach, but also in your heart and blood vessels.
What do they do? They help make stomach acid, which is important for digestion. They also help control your heart rate.
What happens? When histamine connects to H2 receptors, it increases stomach acid, which helps with digestion but can cause problems like heartburn if there's too much.
H3 Receptors:
Where? Mostly in the brain.
What do they do? They help balance brain chemicals that affect how you feel, when you're awake, and how hungry you are.
What happens? When histamine connects to H3 receptors, it helps you stay alert and think clearly.
H4 Receptors:
Where? In bone marrow, white blood cells, and some parts of your digestive system.
What do they do? They help control your immune system, especially when your body is dealing with allergies or inflammation.
What happens? When histamine connects to H4 receptors, it can make inflammation worse, which is important in conditions like asthma or autoimmune diseases.
It turns out that when we live our lives in a constant high level stress, we are releasing granulated histamine from the Mast Cells, which may cause dirty genes, poor detoxification and a whole lot of symptoms that are mis diagnosed as they seem to be un-related.
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